Activin B receptor ALK7 is a negative regulator of pancreatic -cell function
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چکیده
منابع مشابه
Activin B receptor ALK7 is a negative regulator of pancreatic -cell function
All major cell types in pancreatic islets express the transforming growth factor (TGF)superfamily receptor ALK7, but the physiological function of this receptor has been unknown. Mutant mice lacking ALK7 showed normal pancreas organogenesis but developed an age-dependent syndrome involving progressive hyperinsulinemia, reduced insulin sensitivity, liver steatosis, impaired glucose tolerance, an...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0801285105